Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Jon A. Hagar; Daniel A. Powell; Youssef Aachoui; Robert K. Ernst; Edward A. Miao

doi:10.1126/science.1240988

Abstract

Move Over, TLR4 The innate immune system senses bacterial lipopolysaccharide (LPS) through Toll-like receptor 4 (TLR4) (see the Perspective by Kagan ). However, Kayagaki et al. (p 1246 , published online 25 July) and Hagar et al. (p. 1250 ) report that the hexa-acyl lipid A component of LPS from Gramnegative bacteria is able to access the cytoplasm and activate caspase-11 to signal immune responses independently of TLR4. Mice that lack caspase-11 are resistant to LPS-induced lethality, even in the presence of TLR4.

Keywords

PyroptosisLipopolysaccharideCaspaseTLR4Cell biologyBiologyCaspase 1CytosolInnate immune systemCytoplasmCaspase 8Priming (agriculture)ApoptosisProgrammed cell deathSignal transductionImmune systemBiochemistryImmunologyEnzyme

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Publication Info

Year: 2013
Type: article
Volume: 341
Issue: 6151
Pages: 1250-1253
Citations: 1193
Access: Closed

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APA Style

                            
                                
                                    Jon A. Hagar, 
                                
                                    Daniel A. Powell, 
                                
                                    Youssef Aachoui
                                
                                et al.
                            
                            (2013). 
                            Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock. 
                            Science
                            , 341
                            (6151)
                            , 1250-1253.
                            https://doi.org/10.1126/science.1240988
                        

Identifiers

DOI: 10.1126/science.1240988