Abstract
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses. Recent studies have suggested that various DAMPs, such as high-mobility group box 1 (HMGB1), S100 proteins, and heat shock proteins (HSPs), are increased and considered to have a pathogenic role in inflammatory diseases. Here, we review current research on the role of DAMPs in inflammatory diseases, including rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, atherosclerosis, Alzheimer's disease, Parkinson's disease, and cancer. We also discuss the possibility of DAMPs as biomarkers and therapeutic targets for these diseases.
Keywords
Medicine
Affiliated Institutions
Related Publications
DAMP-sensing receptors in sterile inflammation and inflammatory diseases
The innate immune system has the capacity to detect 'non-self' molecules derived from pathogens, known as pathogen-associated molecular patterns, via pattern recognition recepto...
Signaling in Innate Immunity and Inflammation
Inflammation is triggered when innate immune cells detect infection or tissue injury. Surveillance mechanisms involve pattern recognition receptors (PRRs) on the cell surface an...
Pathogen Recognition by the Innate Immune System
Microbial infection initiates complex interactions between the pathogen and the host. Pathogens express several signature molecules, known as pathogen-associated molecular patte...
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
SUMMARY The innate immune system constitutes the first line of defense against invading microbial pathogens and relies on a large family of pattern recognition receptors (PRRs),...
S100A8 and S100A9: DAMPs at the Crossroads between Innate Immunity, Traditional Risk Factors, and Cardiovascular Disease
Amplification of innate immune responses by endogenous danger-associated molecular patterns (DAMPs) promotes inflammation. The involvement of S100A8 and S100A9, DAMPs belonging ...
Publication Info
- Year
- 2018
- Type
- review
- Volume
- 18
- Issue
- 4
- Pages
- e27-e27
- Citations
- 1109
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1109
OpenAlex
Cite This
Jong Seong Roh,
Dong Hyun Sohn
(2018).
Damage-Associated Molecular Patterns in Inflammatory Diseases.
Immune Network
, 18
(4)
, e27-e27.
https://doi.org/10.4110/in.2018.18.e27
Identifiers
- DOI
- 10.4110/in.2018.18.e27