Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

Abstract

Microsatellite instability determines whether patients with gastrointestinal cancer respond exceptionally well to immunotherapy. However, in clinical practice, not every patient is tested for MSI, because this requires additional genetic or immunohistochemical tests. Here we show that deep residual learning can predict MSI directly from H&E histology, which is ubiquitously available. This approach has the potential to provide immunotherapy to a much broader subset of patients with gastrointestinal cancer.

Keywords

Affiliated Institutions

• Kanagawa Cancer Center
• German Cancer Research Center DE
• Charité - Universitätsmedizin Berlin DE
• Kanagawa Prefectural Hospital Organization JP
• University of Chicago US
• University Medical Centre Mannheim DE
• University of Leeds GB
• University Hospital Heidelberg DE
• Heidelberg University DE
• RWTH Aachen University DE

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