Abstract

Brain anatomy revealed in startling detail The mammalian cerebral cortex is an enormously complex network of neuronal processes that are long and thin, branching, and extremely densely packed. This high packing density has made the reconstruction of cortical neuronal networks challenging. Motta et al. used advanced automated imaging and analysis tools to reconstruct with high spatial resolution the morphological features of 89 neurons and their connections in the mouse barrel cortex. The reconstruction covered an area more than two orders of magnitude larger than earlier neuroanatomical mapping attempts. This approach revealed information about the connectivity of inhibitory and excitatory synapses of corticocortical as well as excitatory thalamocortical connections. Science , this issue p. eaay3134

Keywords

NeuropilNeuroscienceExcitatory postsynaptic potentialCortex (anatomy)Somatosensory systemInhibitory postsynaptic potentialNeuronHebbian theoryCerebral cortexBarrel cortexBiologyAnatomyComputer scienceArtificial intelligenceArtificial neural networkCentral nervous system

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Year
2019
Type
article
Volume
366
Issue
6469
Citations
336
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Closed

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Alessandro Motta, Manuel Berning, Kevin M. Boergens et al. (2019). Dense connectomic reconstruction in layer 4 of the somatosensory cortex. Science , 366 (6469) . https://doi.org/10.1126/science.aay3134

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DOI
10.1126/science.aay3134