Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia

Milton B. Yatvin; John N. Weinstein; Warren H. Dennis; Robert Blumenthal

doi:10.1126/science.364652

Abstract

Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia. In a test system in vitro, protein synthesis by Escherichia coli is inhibited and killing of the cells is enhanced by heating neomycin-containing liposomes to their phase transition temperature to maximize drug release. In the presence of serum the ratio of release at 44 degrees C to that at 37 degrees C can be made greater than 100:1, suggesting possible applications in the treatment of tumors or local infection.

Keywords

LiposomeHyperthermiaDrugIn vitroChemistryEscherichia coliNeomycinPharmacologyBiophysicsBiochemistryBiologyAntibioticsMedicineInternal medicine

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Publication Info

Year: 1978
Type: article
Volume: 202
Issue: 4374
Pages: 1290-1293
Citations: 925
Access: Closed

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APA Style

                            
                                
                                    Milton B. Yatvin, 
                                
                                    John N. Weinstein, 
                                
                                    Warren H. Dennis
                                
                                et al.
                            
                            (1978). 
                            Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia. 
                            Science
                            , 202
                            (4374)
                            , 1290-1293.
                            https://doi.org/10.1126/science.364652
                        

Identifiers

DOI: 10.1126/science.364652