Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

2018 Nature Medicine 1,614 citations

Keywords

Chimeric antigen receptorCD8ImmunologyChronic lymphocytic leukemiaAntigenCytotoxic T cellT cellCancer researchBiologyCD19Immune systemLeukemiaMedicineIn vitro

MeSH Terms

AnimalsAntigensCD19FemaleImmunotherapyAdoptiveInterleukin-6LeukemiaLymphocyticChronicB-CellMaleMiceReceptorsChimeric AntigenSTAT3 Transcription FactorTranscriptionGeneticTreatment Outcome

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Publication Info

Year
2018
Type
article
Volume
24
Issue
5
Pages
563-571
Citations
1614
Access
Closed

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Citation Metrics

1614
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55
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Cite This

Joseph A. Fraietta, Simon F. Lacey, Elena J. Orlando et al. (2018). Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia. Nature Medicine , 24 (5) , 563-571. https://doi.org/10.1038/s41591-018-0010-1

Identifiers

DOI
10.1038/s41591-018-0010-1
PMID
29713085
PMCID
PMC6117613

Data Quality

Data completeness: 72%