Abstract
The author obtained a longitudinal psychiatric history from 30 patients with proven Cushing's syndrome. Twenty-five (83%) of the patients met strict diagnostic criteria for an episode of affective disorder during the course of their endocrine disturbance. Twenty patients met criteria for endogenous depression and eight patients also reported an episode of mania or hypomania. Schizophrenic syndromes were not evident, although two patients met criteria for a psychotic depression. Patients frequently attempted to minimize or conceal serious psychiatric disturbance, including a suicide attempt. Typical affective syndromes occurred in patients with adrenocortical tumors as well as in those with ACTH-dependent Cushing's syndrome.
Keywords
Related Publications
Neuroendocrine Response to L-5-Hydroxytryptophan Challenge in Prepubertal Major Depression
The neuroendocrine response to L-5-hydroxytryptophan was compared in 37 prepubertal children who met the Research Diagnostic Criteria for major depressive disorder with that in ...
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
<h3>Objective.</h3> —To assess the validity and utility of PRIME-MD (Primary Care Evaluation of Mental Disorders), a new rapid procedure for diagnosing mental disorders by prima...
Publication Info
- Year
- 1985
- Type
- article
- Volume
- 142
- Issue
- 8
- Pages
- 911-916
- Citations
- 173
- Access
- Closed
External Links
Social Impact
Social media, news, blog, policy document mentions
Citation Metrics
Cite This
Identifiers
- DOI
- 10.1176/ajp.142.8.911