Disease in the scurfy (<i>sf</i>) mouse is associated with overexpression of cytokine genes

Abstract

Abstract The murine X‐linked lymphoproliferative disease scurfy is similar to the Wiskott‐Aldrich syndrome in humans. Disease in scurfy ( sf ) mice is mediated by CD4 + T cells. Based on similarities in scurfy mice and transgenic mice that overexpress specific cytokine genes, we evaluated the expression of cytokines in the lesions of sf mice by Northern blotting, quantitative reverse‐transcription polymerase chain reaction (RT‐PCR) and by hybridization in situ. Overall, the phenotypic characteristics of scurfy disease correlated well with increased interleukin (IL)‐4 (lymphadenopathy), IL‐6 (B cell proliferation, hypergammaglobulinemia), IL‐7 (dermal inflammatory cell infiltration), and high levels of tumor necrosis factor‐α (wasting).

Keywords

BiologyHypergammaglobulinemiaImmunologyCytokineLymphoproliferative disordersLymphomaAntibody

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Publication Info

Year: 1996
Type: article
Volume: 26
Issue: 1
Pages: 161-165
Citations: 120
Access: Closed

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APA Style

                            
                                
                                    Sivadasan Kanangat, 
                                
                                    Patrick J. Blair, 
                                
                                    R Reddy
                                
                                et al.
                            
                            (1996). 
                            Disease in the scurfy (<i>sf</i>) mouse is associated with overexpression of cytokine genes. 
                            European Journal of Immunology
                            , 26
                            (1)
                            , 161-165.
                            https://doi.org/10.1002/eji.1830260125
                        

Identifiers

DOI: 10.1002/eji.1830260125