Abstract

A patient with selective bilateral damage to the amygdala did not acquire conditioned autonomic responses to visual or auditory stimuli but did acquire the declarative facts about which visual or auditory stimuli were paired with the unconditioned stimulus. By contrast, a patient with selective bilateral damage to the hippocampus failed to acquire the facts but did acquire the conditioning. Finally, a patient with bilateral damage to both amygdala and hippocampal formation acquired neither the conditioning nor the facts. These findings demonstrate a double dissociation of conditioning and declarative knowledge relative to the human amygdala and hippocampus.

Keywords

AmygdalaDissociation (chemistry)Hippocampal formationPsychologyNeuroscienceConditioningClassical conditioningStimulus (psychology)Fear conditioningHippocampusCognitive psychologyChemistry

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Publication Info

Year
1995
Type
article
Volume
269
Issue
5227
Pages
1115-1118
Citations
1390
Access
Closed

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Antoine Bechara, Daniel Tranel, Hanna Damásio et al. (1995). Double Dissociation of Conditioning and Declarative Knowledge Relative to the Amygdala and Hippocampus in Humans. Science , 269 (5227) , 1115-1118. https://doi.org/10.1126/science.7652558

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DOI
10.1126/science.7652558