EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

Abstract

In response to major changes in diagnostic algorithms and the publication of mature results from various large clinical trials, the European Association of Neuro-Oncology (EANO) recognized the need to provide updated guidelines for the diagnosis and management of adult patients with diffuse gliomas. Through these evidence-based guidelines, a task force of EANO provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. The diagnostic component is based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System and the subsequent recommendations of the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy — Not Officially WHO (cIMPACT-NOW). With regard to therapy, we formulated recommendations based on the results from the latest practice-changing clinical trials and also provide guidance for neuropathological and neuroradiological assessment. In these guidelines, we define the role of the major treatment modalities of surgery, radiotherapy and systemic pharmacotherapy, covering current advances and cognizant that unnecessary interventions and expenses should be avoided. This document is intended to be a source of reference for professionals involved in the management of adult patients with diffuse gliomas, for patients and caregivers, and for health-care providers. Herein, the European Association of Neuro-Oncology (EANO) provides recommendations for the diagnosis, treatment and follow-up of adult patients with diffuse gliomas. These evidence-based guidelines incorporate major changes in diagnostic algorithms based on the 2016 update of the WHO Classification of Tumors of the Central Nervous System as well as on evidence from recent large clinical trials.

Keywords

MeSH Terms

Affiliated Institutions

• University of Siena IT
• Heinrich Heine University Düsseldorf DE
• LMU Klinikum DE
• Hospital Universitari Germans Trias i Pujol ES
• Medical University of Vienna AT
• University Hospital Heidelberg DE
• Assistance Publique Hôpitaux de Marseille FR
• University of Zurich CH
• St James's University Hospital GB
• University Hospital of Zurich CH
• Aix-Marseille Université FR
• Leiden University Medical Center NL
• Sahlgrenska University Hospital SE
• Erasmus MC Cancer Institute NL
• Universität Hamburg DE
• National Center for Tumor Diseases DE
• Medisch Centrum Haaglanden NL
• Institut Català d'Oncologia ES
• Erasmus MC NL
• Ludwig-Maximilians-Universität München DE
• Heidelberg University DE
• Erasmus University Rotterdam NL

Related Publications