Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention

Abstract

Following PCI, long-term (1-year) clopidogrel therapy significantly reduced the risk of adverse ischemic events. A loading dose of clopidogrel given at least 3 hours before the procedure did not reduce events at 28 days, but subgroup analyses suggest that longer intervals between the loading dose and PCI may reduce events.

Keywords

MedicineClopidogrelPercutaneous coronary interventionConventional PCIAspirinMyocardial infarctionPopulationLoading dosePlaceboInternal medicineTiclopidineRandomized controlled trialCardiologySurgery

Affiliated Institutions

Related Publications

Dose Effect of Clopidogrel Reloading in Patients Already on 75-mg Maintenance Dose

Jean‐Philippe Collet , Johanne Silvain , Antoine Landivier +8 more

Background— Clopidogrel loading has mostly been studied in clopidogrel-naïve patients. Whether clopidogrel-treated patients readmitted for an acute coronary syndrome or percuta...

2008 Circulation 87 citations

Randomized Comparison of Prasugrel (CS-747, LY640315), a Novel Thienopyridine P2Y <sub>12</sub> Antagonist, With Clopidogrel in Percutaneous Coronary Intervention

Stephen D. Wiviott , Elliott M. Antman , Kenneth J. Winters +8 more

Background— Despite the current standard antiplatelet regimen of aspirin and clopidogrel (with or without glycoprotein IIb/IIIa inhibitors) in percutaneous coronary intervention...

2005 Circulation 378 citations

Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome

John H. Alexander , Renato D. Lópes , Stefan James +31 more

The addition of apixaban, at a dose of 5 mg twice daily, to antiplatelet therapy in high-risk patients after an acute coronary syndrome increased the number of major bleeding ev...

2011 New England Journal of Medicine 990 citations

Design of ESPRIT: An International Randomized Trial for Secondary Prevention after Non-Disabling Cerebral Ischaemia of Arterial Origin

E.L.L.M. De Schryver

The ESPRIT trial addresses the problem that aspirin, the standard therapy for secondary prevention of vascular complications after a transient ischaemic attack (TIA) or ischaemi...

2000 Cerebrovascular Diseases 98 citations

Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation

Renato D. Lópes , Gretchen Heizer , Ronald Aronson +19 more

In patients with atrial fibrillation and a recent acute coronary syndrome or PCI treated with a P2Y<sub>12</sub> inhibitor, an antithrombotic regimen that included apixaban, wit...

2019 New England Journal of Medicine 1106 citations

Publication Info

Year: 2002
Type: article
Volume: 288
Issue: 19
Pages: 2411-2411
Citations: 3065
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

3065

OpenAlex

Cite This

APA Style

                            
                                
                                    Steven R. Steinhubl, 
                                
                                    Peter B. Berger, 
                                
                                    J. Tift Mann
                                
                                et al.
                            
                            (2002). 
                            Early and Sustained Dual Oral Antiplatelet Therapy Following Percutaneous Coronary Intervention. 
                            JAMA
                            , 288
                            (19)
                            , 2411-2411.
                            https://doi.org/10.1001/jama.288.19.2411
                        

Identifiers

DOI: 10.1001/jama.288.19.2411