Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension

Abstract

Low-dose diuretic-based (chlorthalidone) treatment is effective in preventing major CVD events, cerebral and cardiac, in both non-insulin-treated diabetic and nondiabetic older patients with ISH.

Keywords

MedicineChlorthalidoneInternal medicineAtenololDiureticDiabetes mellitusBlood pressurePlaceboSystolic hypertensionMyocardial infarctionCardiologyStroke (engine)Endocrinology

Affiliated Institutions

Related Publications

Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies

M R Law , Joan K. Morris , Nicholas Wald

With the exception of the extra protective effect of beta blockers given shortly after a myocardial infarction and the minor additional effect of calcium channel blockers in pre...

2009 BMJ 2727 citations

Impact of Age on the Importance of Systolic and Diastolic Blood Pressures for Stroke Risk

Julie K.K. Vishram , Anders Borglykke , Anne Helms Andreasen +13 more

This study investigates age-related shifts in the relative importance of systolic (SBP) and diastolic (DBP) blood pressures as predictors of stroke and whether these relations a...

2012 Hypertension 115 citations

Blood pressure, antihypertensive drug treatment and the risks of stroke and of coronary heart disease

Rory Collins , Stephen MacMahon

Most evidence about the effects of blood pressure on the risks of cardiovascular disease derives from two principal sources: prospective non-randomised observational studies of ...

1994 British Medical Bulletin 589 citations

Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk Patients

Salim Yusuf , Peter Sleight , Janice Pogue +3 more

Ramipril significantly reduces the rates of death, myocardial infarction, and stroke in a broad range of high-risk patients who are not known to have a low ejection fraction or ...

2000 New England Journal of Medicine 8597 citations

Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials

Costas Thomopoulos , Gianfranco Parati , Alberto Zanchetti

Meta-analyses of all BP-lowering RCTs involving hypertensive patients provide precise estimates of benefits (larger for stroke and heart failure, but also significant for CHD an...

2014 Journal of Hypertension 364 citations

Publication Info

Year: 1996
Type: article
Volume: 276
Issue: 23
Pages: 1886-1886
Citations: 935
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

935

OpenAlex

Cite This

APA Style

                            
                                
                                    J. David Curb, 
                                
                                    Sara Pressel, 
                                
                                    Jeffrey A. Cutler
                                
                                et al.
                            
                            (1996). 
                            Effect of Diuretic-Based Antihypertensive Treatment on Cardiovascular Disease Risk in Older Diabetic Patients With Isolated Systolic Hypertension. 
                            JAMA
                            , 276
                            (23)
                            , 1886-1886.
                            https://doi.org/10.1001/jama.1996.03540230036032
                        

Identifiers

DOI: 10.1001/jama.1996.03540230036032