Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases

Abstract

Endothelial cells appear to express phosphorylated PDGF-R when they are exposed to tumor cells that express PDGF. Using STI571 to inhibit PDGF-R phosphorylation may, especially in combination with paclitaxel, produce substantial therapeutic effects against prostate cancer bone metastasis.

Keywords

Platelet-derived growth factor receptorPlatelet-derived growth factorBone metastasisProstate cancerMedicineCancer researchGrowth factorMetastasisPathologyEndocrinologyInternal medicineCancerReceptor

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Publication Info

Year: 2003
Type: article
Volume: 95
Issue: 6
Pages: 458-470
Citations: 278
Access: Closed

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APA Style

                            
                                
                                    Hisanori Uehara, 
                                
                                    Seung Jun Kim, 
                                
                                    Takashi Karashima
                                
                                et al.
                            
                            (2003). 
                            Effects of Blocking Platelet-Derived Growth Factor-Receptor Signaling in a Mouse Model of Experimental Prostate Cancer Bone Metastases. 
                            JNCI Journal of the National Cancer Institute
                            , 95
                            (6)
                            , 458-470.
                            https://doi.org/10.1093/jnci/95.6.458
                        

Identifiers

DOI: 10.1093/jnci/95.6.458