Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis

Xinfang Xie; Emily Atkins; Jicheng Lv; Alexander Bennett; Bruce Neal; Toshiharu Ninomiya; Mark Woodward; Stephen MacMahon; Fiona Turnbull; Graham S. Hillis; John Chalmers; Jonathan Mant; Abdul Salam; Kazem Rahimi; Vlado Perkovic; Anthony Rodgers

doi:10.1371/journal.pmed.1001293

Abstract

Intensive BP lowering regimens provided greater vascular protection than standard regimens that was proportional to the achieved difference in systolic BP, but did not have any clear impact on the risk of death or serious adverse events. Further trials are required to more clearly define the risks and benefits of BP targets below those currently recommended, given the benefits suggested by the currently available data.

Keywords

MedicineBlood pressureStroke (engine)Myocardial infarctionInternal medicineMeta-analysisIntensive careRelative riskAlbuminuriaPlaceboKidney diseaseAdverse effectCochrane LibraryCardiologyIntensive care medicineConfidence intervalPathology

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Publication Info

Year: 2012
Type: review
Volume: 9
Issue: 8
Pages: e1001293-e1001293
Citations: 778
Access: Closed

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APA Style

                            
                                
                                    Xinfang Xie, 
                                
                                    Emily Atkins, 
                                
                                    Jicheng Lv
                                
                                et al.
                            
                            (2012). 
                            Effects of Intensive Blood Pressure Lowering on Cardiovascular and Renal Outcomes: A Systematic Review and Meta-Analysis. 
                            PLoS Medicine
                            , 9
                            (8)
                            , e1001293-e1001293.
                            https://doi.org/10.1371/journal.pmed.1001293
                        

Identifiers

DOI: 10.1371/journal.pmed.1001293