Effects of Intensive Glucose Lowering in Type 2 Diabetes

Abstract

As compared with standard therapy, the use of intensive therapy to target normal glycated hemoglobin levels for 3.5 years increased mortality and did not significantly reduce major cardiovascular events. These findings identify a previously unrecognized harm of intensive glucose lowering in high-risk patients with type 2 diabetes. (ClinicalTrials.gov number, NCT00000620.)

Keywords

MedicineGlycated hemoglobinHazard ratioInternal medicineType 2 diabetesConfidence intervalDiscontinuationDiabetes mellitusMyocardial infarctionRandomized controlled trialEndocrinology

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Publication Info

Year: 2008
Type: article
Volume: 358
Issue: 24
Pages: 2545-2559
Citations: 7743
Access: Closed

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APA Style

                            
                                
                                    Hertzel C. Gerstein, 
                                
                                    Michael E. Miller, 
                                
                                    Robert P. Byington
                                
                                et al.
                            
                            (2008). 
                            Effects of Intensive Glucose Lowering in Type 2 Diabetes. 
                            New England Journal of Medicine
                            , 358
                            (24)
                            , 2545-2559.
                            https://doi.org/10.1056/nejmoa0802743
                        

Identifiers

DOI: 10.1056/nejmoa0802743