Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

Lesley J. Wood; Matthias Egger; Lise Lotte Gluud; Kenneth F. Schulz; Peter Jüni; Douglas G. Altman; Christian Gluud; Richard M. Martin; Anthony J G Wood; Jonathan A C Sterne

doi:10.1136/bmj.39465.451748.ad

Abstract

The average bias associated with defects in the conduct of randomised trials varies with the type of outcome. Systematic reviewers should routinely assess the risk of bias in the results of trials, and should report meta-analyses restricted to trials at low risk of bias either as the primary analysis or in conjunction with less restrictive analyses.

Keywords

BlindingMeta-analysisOdds ratioMedicinePsychological interventionPublication biasRandomized controlled trialEpidemiologyOddsClinical trialSelection biasInternal medicineLogistic regressionPsychiatryPathology

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Publication Info

Year: 2008
Type: article
Volume: 336
Issue: 7644
Pages: 601-605
Citations: 2507
Access: Closed

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APA Style

                            
                                
                                    Lesley J. Wood, 
                                
                                    Matthias Egger, 
                                
                                    Lise Lotte Gluud
                                
                                et al.
                            
                            (2008). 
                            Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. 
                            BMJ
                            , 336
                            (7644)
                            , 601-605.
                            https://doi.org/10.1136/bmj.39465.451748.ad
                        

Identifiers

DOI: 10.1136/bmj.39465.451748.ad