Energy on Demand

Pierre J. Magistretti; Luc Pellerin; Douglas L. Rothman; Robert G. Shulman

doi:10.1126/science.283.5401.496

Abstract

New imaging techniques can see into the functioning brain, revealing the regions that are active during certain tasks and sensations. Magistretti et al., in their Perspective, take this notion one step further and, by careful analysis of the biochemistry that gives rise to imaging signals, they deduce some of the cellular and molecular events that accompany neuronal activity in the working brain, ultimately laying the groundwork for determining the biochemistry that underlies human cognition.

Keywords

Perspective (graphical)Cognitive scienceNeuroscienceCognitionEnergy (signal processing)Energy metabolismPsychologyComputer scienceBiologyArtificial intelligencePhysics

MeSH Terms

Adenosine TriphosphateAnimalsAstrocytesBehaviorAnimalBrainBrain MappingCognitionEnergy MetabolismGlucoseGlutamic AcidGlutamineMagnetic Resonance ImagingNeuronsNeurotransmitter AgentsOxidation-ReductionSodiumSynapsesSynaptic TransmissionTomographyEmission-Computed

Affiliated Institutions

Related Publications

Stimulus-specific neuronal oscillations in orientation columns of cat visual cortex.

Charles M. Gray , W. Singer

In areas 17 and 18 of the cat visual cortex the firing probability of neurons, in response to the presentation of optimally aligned light bars within their receptive field, osci...

1989 Proceedings of the National Academy o... 2492 citations

Impact of Network Activities on Neuronal Properties in Corticothalamic Systems

Mircea Steriade

Data from in vivo and in vitro experiments are discussed to emphasize that synaptic activities in neocortex and thalamus have a decisive impact on intrinsic neuronal properties ...

2001 Journal of Neurophysiology 535 citations

How GABA generates depolarization

Nicholas C. Spitzer

In a masterful, insightful and influential paper published in The Journal of Physiology in 1989, Ben-Ari, Cherubini, Corradetti and Giarsa understood for the first time the basi...

2010 The Journal of Physiology 39 citations

THE ULTRASTRUCTURE OF MAUTHNER CELL SYNAPSES AND NODES IN GOLDFISH BRAINS

J. David Robertson , Thomas Bodenheimer , David E. Stage

An electron microscope study of goldfish Mauthner cells is reported.1 The cell is covered by a synaptic bed ∼ 5 µ thick containing unusual amounts of extracellular matrix materi...

1963 The Journal of Cell Biology 354 citations

Perception without awareness: Cognitive, clinical, and social perspectives.

Robert F. Bornstein , Thane S. Pittman

This landmark volume brings together the work of the world's leading researchers in sublimated perception. This compilation marks a fundamental shift in the current study of sub...

1992 167 citations

Publication Info

Year: 1999
Type: article
Volume: 283
Issue: 5401
Pages: 496-497
Citations: 1150
Access: Closed

External Links

View on DOI.org PubMed

Social Impact

Altmetric

Energy on Demand

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

1150

OpenAlex

972

CrossRef

Cite This

APA Style

                            
                                
                                    Pierre J. Magistretti, 
                                
                                    Luc Pellerin, 
                                
                                    Douglas L. Rothman
                                
                                et al.
                            
                            (1999). 
                            Energy on Demand. 
                            Science
                            , 283
                            (5401)
                            , 496-497.
                            https://doi.org/10.1126/science.283.5401.496
                        

Identifiers

DOI: 10.1126/science.283.5401.496
PMID: 9988650

Data Quality

Data completeness: 81%