Abstract

Exosomes are cell-derived nanovesicles that are involved in the intercellular transportation of materials. Therapeutics, such as small molecules or nucleic acid drugs, can be incorporated into exosomes and then delivered to specific types of cells or tissues to realize targeted drug delivery. Targeted delivery increases the local concentration of therapeutics and minimizes side effects. Here, we present a detailed review of exosomes engineering through genetic and chemical methods for targeted drug delivery. Although still in its infancy, exosome-mediated drug delivery boasts low toxicity, low immunogenicity, and high engineerability, and holds promise for cell-free therapies for a wide range of diseases.

Keywords

MicrovesiclesDrug deliveryImmunogenicityExosomeTargeted drug deliveryDrugNucleic acidNanotechnologyChemistryPharmacologyMedicinemicroRNAImmune systemImmunologyMaterials scienceBiochemistry

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Publication Info

Year
2021
Type
review
Volume
11
Issue
7
Pages
3183-3195
Citations
1246
Access
Closed

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Cite This

Yujie Liang, Li Duan, Jianping Lu et al. (2021). Engineering exosomes for targeted drug delivery. Theranostics , 11 (7) , 3183-3195. https://doi.org/10.7150/thno.52570

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DOI
10.7150/thno.52570