Abstract
Examining the pattern of nucleotide substitution for the control region of mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new mathematical method for estimating the number of transitional and transversional substitutions per site, as well as the total number of nucleotide substitutions. In this method, excess transitions, unequal nucleotide frequencies, and variation of substitution rate among different sites are all taken into account. Application of this method to human and chimpanzee data suggested that the transition/transversion ratio for the entire control region was approximately 15 and nearly the same for the two species. The 95% confidence interval of the age of the common ancestral mtDNA was estimated to be 80,000-480,000 years in humans and 0.57-2.72 Myr in common chimpanzees.
Keywords
TransversionBiologyMitochondrial DNAmtDNA control regionGeneticsNucleotideTransition (genetics)Substitution (logic)Evolutionary biologyMolecular clockPhylogeneticsMutationGeneHaplotypeGenotype
Affiliated Institutions
Related Publications
HUMAN MITOCHONDRIAL DNA VARIATION AND EVOLUTION: ANALYSIS OF NUCLEOTIDE SEQUENCES FROM SEVEN INDIVIDUALS
ABSTRACT We have analyzed nucleotide sequence variation in an approximately 900-base pair region of the human mitochondrial DNA molecule encompassing the heavy strand origin of ...
Novel features of animal mtDNA evolution as shown by sequences of two rat cytochrome oxidase subunit II genes.
The sequence of the region of the mitochondrial genome that encodes cytochrome oxidase subunit II (COII) has been determined for each of two closely related rat species, Rattus ...
Evolutionary tree for apes and humans based on cleavage maps of mitochondrial DNA.
The high rate of evolution of mitochondrial DNA makes this molecule suitable for genealogical research on such closely related species as humans and apes. Because previous appro...
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated. Large-scale scre...
Direct estimates of human per nucleotide mutation rates at 20 loci causing mendelian diseases
I estimate per nucleotide rates of spontaneous mutations of different kinds in humans directly from the data on per locus mutation rates and on sequences of de novo nonsense nuc...
Publication Info
- Year
- 1993
- Type
- article
- Volume
- 10
- Issue
- 3
- Pages
- 512-26
- Citations
- 11298
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
11298
OpenAlex
Cite This
Koichiro Tamura,
M Nei
(1993).
Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees..
Molecular Biology and Evolution
, 10
(3)
, 512-26.
https://doi.org/10.1093/oxfordjournals.molbev.a040023
Identifiers
- DOI
- 10.1093/oxfordjournals.molbev.a040023