Abstract

Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To explore the evolution of protein phosphorylation, we compared the protein kinase complements ('kinomes') of budding yeast, worm and fly, with known human kinases. We classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique, expanded or lost in each lineage. Fly and human share several kinase families involved in immunity, neurobiology, cell cycle and morphogenesis that are absent from worm, suggesting that these functions might have evolved after the divergence of nematodes from the main metazoan lineage.

Keywords

BiologyKinaseLineage (genetic)Cell biologyPhosphorylationYeastProtein kinase ASignal transductionGeneticsGene

MeSH Terms

AnimalsEvolutionMolecularHumansPhosphorylationPhylogenyProtein KinasesProtein StructureTertiarySaccharomyces cerevisiaeSequence HomologySignal Transduction

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Publication Info

Year
2002
Type
review
Volume
27
Issue
10
Pages
514-520
Citations
988
Access
Closed

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Cite This

Gerard Manning, Gregory D. Plowman, Tony Hunter et al. (2002). Evolution of protein kinase signaling from yeast to man. Trends in Biochemical Sciences , 27 (10) , 514-520. https://doi.org/10.1016/s0968-0004(02)02179-5

Identifiers

DOI
10.1016/s0968-0004(02)02179-5
PMID
12368087

Data Quality

Data completeness: 81%