Abstract
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
Keywords
OxygenaseHydroxylationDemethylationHistoneBiochemistryMetabolic pathwayBiologyChemical biologyNucleic acid metabolismMetabolismSecondary metabolismComputational biologyChemistryBiosynthesisGeneEnzymeGene expressionDNA methylationRNA
MeSH Terms
AnimalsCatalysisHistonesHumansHydroxylationKetoglutaric AcidsMethylationModelsMolecularNucleic AcidsOxidation-ReductionOxygenasesProteinsSignal TransductionStereoisomerism
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Publication Info
- Year
- 2008
- Type
- article
- Volume
- 4
- Issue
- 3
- Pages
- 152-156
- Citations
- 488
- Access
- Closed
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Cite This
Christoph Loenarz,
Christopher J. Schofield
(2008).
Expanding chemical biology of 2-oxoglutarate oxygenases.
Nature Chemical Biology
, 4
(3)
, 152-156.
https://doi.org/10.1038/nchembio0308-152
Identifiers
- DOI
- 10.1038/nchembio0308-152
- PMID
- 18277970