Exploring modularity in biological networks

2020 Philosophical Transactions of the Royal Society B Biological Sciences 44 citations

Abstract

Network theoretical approaches have shaped our understanding of many different kinds of biological modularity. This essay makes the case that to capture these contributions, it is useful to think about the role of network models in exploratory research. The overall point is that it is possible to provide a systematic analysis of the exploratory functions of network models in bioscientific research. Using two examples from molecular and developmental biology, I argue that often the same modelling approach can perform one or more exploratory functions, such as introducing new directions of research, offering a complementary set of concepts, methods and algorithms for individuating important features of natural phenomena, generating proofs of principle demonstrations and potential explanations for phenomena of interest and enlarging the scope of certain research agendas. This article is part of the theme issue ‘Unifying the essential concepts of biological networks: biological insights and philosophical foundations’.

Keywords

Modularity (biology)Scope (computer science)Computer scienceBiological networkMathematical proofSet (abstract data type)Data scienceTheme (computing)Cognitive scienceManagement scienceEpistemologyBiologyPsychologyComputational biologyMathematics

MeSH Terms

AlgorithmsBiologyComputer SimulationModelsBiological

Affiliated Institutions

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Publication Info

Year
2020
Type
article
Volume
375
Issue
1796
Pages
20190316-20190316
Citations
44
Access
Closed

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Cite This

Maria Şerban (2020). Exploring modularity in biological networks. Philosophical Transactions of the Royal Society B Biological Sciences , 375 (1796) , 20190316-20190316. https://doi.org/10.1098/rstb.2019.0316

Identifiers

DOI
10.1098/rstb.2019.0316
PMID
32089119
PMCID
PMC7061960

Data Quality

Data completeness: 86%