Abstract

Regulatory CD25 + CD4 + T cells are considered as important players in T cell homeostasis and self-tolerance. Here we report that the integrin α E β 7 , which recognizes epithelial cadherin, identifies the most potent subpopulation of regulatory CD25 + T cells. Strikingly, CD25-negative α E + CD4 + T cells displayed regulatory activity. Both α E + subsets, CD25 + and CD25 − , express CTLA-4, suppress T cell proliferation in vitro , and protect mice from colitis in the severe combined immunodeficient model (SCID) in vivo . Whereas α E + CD25 + T cells produce almost no cytokines, α E + CD25 − T cells represent a unique subset in which high IL-2, IFN-γ and T helper 2-cytokine production is linked with suppressive function. Thus, the integrin α E β 7 can be regarded as a novel marker for subsets of highly potent, functionally distinct regulatory T cells specialized for crosstalk with epithelial environments.

Keywords

IL-2 receptorBiologyCytokineCell biologyMolecular biologyT cellImmunologyImmune system

MeSH Terms

AnimalsCD4-Positive T-LymphocytesCell DivisionCell SeparationCytokinesFemaleFlow CytometryHomeostasisIntegrinsInterferon-gammaLeukocyte Common AntigensMiceMiceInbred BALB CMiceInbred C57BLMiceSCIDReceptorsInterleukin-2T-Lymphocyte SubsetsT-LymphocytesTh2 CellsTime Factors

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Publication Info

Year
2002
Type
article
Volume
99
Issue
20
Pages
13031-13036
Citations
456
Access
Closed

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Joachim Lehmann, Jochen Huehn, Maurus de la Rosa et al. (2002). Expression of the integrin α<sub>E</sub>β<sub>7</sub>identifies unique subsets of CD25<sup>+</sup>as well as CD25<sup>−</sup>regulatory T cells. Proceedings of the National Academy of Sciences , 99 (20) , 13031-13036. https://doi.org/10.1073/pnas.192162899

Identifiers

DOI
10.1073/pnas.192162899
PMID
12242333
PMCID
PMC130581

Data Quality

Data completeness: 86%