Abstract
Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.
Keywords
Drug deliveryNanotechnologyTargeted drug deliveryNanoparticleDrugNanomedicineMaterials scienceComputer scienceRisk analysis (engineering)MedicinePharmacology
Affiliated Institutions
Related Publications
Block Copolymer Micelles in Nanomedicine Applications
Polymeric micelles are demonstrating high potential as nanomedicines capable of controlling the distribution and function of loaded bioactive agents in the body, effectively ove...
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital compon...
Surface functionalization of polymeric nanoparticles for tumor drug delivery: approaches and challenges
For years, injectable polymeric nanoparticles (NPs) have been developed for delivering therapeutic agents to the tumors. Frequently, NPs surface have been modified with differen...
Nanoparticles in the clinic: An update
Abstract Nanoparticle drug delivery systems have been used in the clinic since the early 1990's. Since that time, the field of nanomedicine has evolved alongside growing technol...
Nanoparticles in Medicine: Therapeutic Applications and Developments
Nanotechnology is the understanding and control of matter generally in the 1-100 nm dimension range. The application of nanotechnology to medicine, known as nanomedicine, concer...
Publication Info
- Year
- 2013
- Type
- article
- Volume
- 7
- Issue
- 9
- Pages
- 7442-7447
- Citations
- 514
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
514
OpenAlex
Cite This
Kinam Park
(2013).
Facing the Truth about Nanotechnology in Drug Delivery.
ACS Nano
, 7
(9)
, 7442-7447.
https://doi.org/10.1021/nn404501g
Identifiers
- DOI
- 10.1021/nn404501g