Figure 7 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition

Yura Grabovska , Rebecca F. Rogers , Maria Antonietta Ajmone‐Cat ,

2025 0 citations

Abstract

<p>Efficacy of combined dasatinib and trametinib on <i>ex vivo</i> brain slice preparations. <b>A,</b> Coronal slices of normal mouse brain, counterstained with Hoechst 33342 (aqua), are implanted in the pontine region with ICR-B169 parental cells, stained with human nuclear antigen (orange), and treated for 4 days with 1 μmol/L dasatinib, 0.1234 μmol/L trametinib, or both compared with vehicle control. Scale bars, 2 mm. <b>B,</b> Bar plot of quantification of tumor cell infiltration across the brain parenchymal tissue as measured by the calculated area invaded compared with vehicle control. Plotted is the mean of at least six independent slices; error bars represent the SD. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01; ***, <i>P</i> < 0.001; ****, <i>P</i> < 0.0001; ns, not significant, FDR-corrected <i>t</i> test.</p>

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Year: 2025
Type: article
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APA Style

                            
                                    Yura Grabovska, 
                                
                                    Rebecca F. Rogers, 
                                
                                    Maria Antonietta Ajmone‐Cat
                                
                                et al.
                            
                            (2025). 
                            Figure 7 from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition. 
                            
                            .
                            https://doi.org/10.1158/2159-8290.30834133

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DOI: 10.1158/2159-8290.30834133