Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Keywords

FluorineChemistryCombinatorial chemistryOrganic chemistry

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2001 Journal of the American Chemical Society 140 citations

Publication Info

Year
2007
Type
review
Volume
37
Issue
2
Pages
320-330
Citations
7190
Access
Closed

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Cite This

Sophie Purser, Peter R. Moore, Steve Swallow et al. (2007). Fluorine in medicinal chemistry. Chemical Society Reviews , 37 (2) , 320-330. https://doi.org/10.1039/b610213c

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DOI
10.1039/b610213c