Abstract
▪ Abstract Focal adhesions are sites of tight adhesion to the underlying extracellular matrix developed by cells in culture. They provide a structural link between the actin cytoskeleton and the extracellular matrix and are regions of signal transduction that relate to growth control. The assembly of focal adhesions is regulated by the GTP-binding protein Rho. Rho stimulates contractility which, in cells that are tightly adherent to the substrate, generates isometric tension. In turn, this leads to the bundling of actin filaments and the aggregation of integrins (extracellular matrix receptors) in the plane of the membrane. The aggregation of integrins activates the focal adhesion kinase and leads to the assembly of a multicomponent signaling complex.
Keywords
Focal adhesionCell biologyExtracellular matrixPTK2IntegrinBiologySignal transductionActin cytoskeletonCytoskeletonActinFibronectinExtracellularReceptorCellProtein kinase CBiochemistryMitogen-activated protein kinase kinase
Affiliated Institutions
Related Publications
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Many cells grown in tissue culture adhere tightly to the underlying substrate through discrete regions of the plasma membrane, referred to as adhesion plaques, focal contacts, o...
Nitric Oxide Controls Src Kinase Activity through a Sulfhydryl Group Modification-mediated Tyr-527-independent and Tyr-416-linked Mechanism
c-Src kinase was activated when either murine NIH3T3 fibroblast cells or immunoprecipitated c-Src proteins were treated with nitric oxide generator, S-nitroso-N-acetyl penicilla...
Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species
Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several...
Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins.
Phagocytosis by monocytes or neutrophils can be enhanced by interaction with several proteins or synthetic peptides containing the Arg-Gly-Asp sequence. Recently we showed that ...
Integrins and other cell adhesion molecules
Cell‐cell and cell‐substratum interactions are mediated through several different families of receptors. In addition to targeting cell adhesion to specific extracellular matrix ...
Publication Info
- Year
- 1996
- Type
- review
- Volume
- 12
- Issue
- 1
- Pages
- 463-519
- Citations
- 1951
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1951
OpenAlex
Cite This
Keith Burridge,
Magdalena Chrzanowska‐Wodnicka
(1996).
FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING.
Annual Review of Cell and Developmental Biology
, 12
(1)
, 463-519.
https://doi.org/10.1146/annurev.cellbio.12.1.463
Identifiers
- DOI
- 10.1146/annurev.cellbio.12.1.463