Functional Consequences of Integrin Gene Mutations in Mice

Daniel Bouvard; Cord Brakebusch; Erika Gustafsson; Attila Aszódi; Therése Bengtsson; Alejandro Berna‐Erro; Reinhard Fässler

doi:10.1161/hh1501.094874

Abstract

Integrins are cell-surface receptors responsible for cell attachment to extracellular matrices and to other cells. The application of mouse genetics has significantly increased our understanding of integrin function in vivo. In this review, we summarize the phenotypes of mice carrying mutant integrin genes and compare them with phenotypes of mice lacking the integrin ligands.

Keywords

IntegrinPhenotypeBiologyCell biologyMutantGeneCollagen receptorExtracellular matrixReceptorFunction (biology)Cell adhesionCellIntegrinbeta 6Genetics

Affiliated Institutions

Lund University SE

Related Publications

Integrins and other cell adhesion molecules

Steven Μ. Albelda , Clayton A. Buck

Cell‐cell and cell‐substratum interactions are mediated through several different families of receptors. In addition to targeting cell adhesion to specific extracellular matrix ...

1990 The FASEB Journal 1970 citations

Characterization of the integrin alpha v beta 6 as a fibronectin-binding protein.

Morten Busk , Robert Pytela , Dean Sheppard

Integrins are a complex family of divalent cation-dependent cell adhesion receptors composed of one alpha and one beta subunit noncovalently bound to one another. A subset of in...

1992 Journal of Biological Chemistry 290 citations

The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation

David Calderwood , Roy Zent , Richard P. Grant +3 more

The beta subunit cytoplasmic domains of integrin adhesion receptors are necessary for the connection of these receptors to the actin cytoskeleton. The cytoplasmic protein, talin...

1999 Journal of Biological Chemistry 709 citations

The Phosphotyrosine Binding-like Domain of Talin Activates Integrins

David Calderwood , Boxu Yan , José M. de Pereda +4 more

Cellular regulation of the ligand binding affinity of integrin adhesion receptors (integrin activation) depends on the integrin beta cytoplasmic domains (tails). The head domain...

2002 Journal of Biological Chemistry 400 citations

The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin.

Helen Cooper , Richard N. Tamura , Vito Quaranta

Laminin is the first extracellular matrix protein expressed in the developing mouse embryo. It is known to influence morphogenesis and affect cell migration and polarization. Se...

1991 The Journal of Cell Biology 160 citations

Publication Info

Year: 2001
Type: review
Volume: 89
Issue: 3
Pages: 211-223
Citations: 259
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Functional Consequences of Integrin Gene Mutations in Mice

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

259

OpenAlex

Cite This

APA Style

                            
                                
                                    Daniel Bouvard, 
                                
                                    Cord Brakebusch, 
                                
                                    Erika Gustafsson
                                
                                et al.
                            
                            (2001). 
                            Functional Consequences of Integrin Gene Mutations in Mice. 
                            Circulation Research
                            , 89
                            (3)
                            , 211-223.
                            https://doi.org/10.1161/hh1501.094874
                        

Identifiers

DOI: 10.1161/hh1501.094874