Abstract

Functional magnetic resonance imaging (fMRI) has become an essential tool for studying human brain function. Here we describe the application of this technique to anesthetized monkeys. We present spatially resolved functional images of the monkey cortex based on blood oxygenation level dependent (BOLD) contrast. Checkerboard patterns or pictures of primates were used to study stimulus-induced activation of the visual cortex, in a 4.7-Tesla magnetic field, using optimized multi-slice, gradient-recalled, echo-planar imaging (EPI) sequences to image the entire brain. Under our anesthesia protocol, visual stimulation yielded robust, reproducible, focal activation of the lateral geniculate nucleus (LGN), the primary visual area (V1) and a number of extrastriate visual areas, including areas in the superior temporal sulcus. Similar responses were obtained in alert, behaving monkeys performing a discrimination task.

Keywords

NeuroscienceLateral geniculate nucleusVisual cortexFunctional magnetic resonance imagingExtrastriate cortexStimulus (psychology)Visual systemBrain mappingFunctional imagingPsychology

MeSH Terms

AnimalsBrainDiscriminationPsychologicalGeniculate BodiesMacaca mulattaMagnetic Resonance ImagingOxygenPhotic StimulationTime FactorsVisual CortexVisual Pathways

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Publication Info

Year
1999
Type
article
Volume
2
Issue
6
Pages
555-562
Citations
543
Access
Closed

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Cite This

Nikos K. Logothetis, H. Guggenberger, Sharon Peled et al. (1999). Functional imaging of the monkey brain. Nature Neuroscience , 2 (6) , 555-562. https://doi.org/10.1038/9210

Identifiers

DOI
10.1038/9210
PMID
10448221

Data Quality

Data completeness: 81%