GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors

Abstract

Adult neurogenesis is tightly regulated through the interaction of neural stem/progenitor cells (NSCs) with their niche. Neurotransmitters, including GABA activation of GABAA receptor ion channels, are important niche signals. We show that adult mouse hippocampal NSCs and their progeny express metabotropic GABAB receptors. Pharmacological inhibition of GABAB receptors stimulated NSC proliferation and genetic deletion of GABAB1 receptor subunits increased NSC proliferation and differentiation of neuroblasts in vivo. Cell-specific conditional deletion of GABAB receptors supports a cell-autonomous role in newly generated cells. Our data indicate that signaling through GABAB receptors is an inhibitor of adult neurogenesis.

Keywords

GABAB receptorNeurogenesisBiologyNeuroblastNeural stem cellMetabotropic receptorGABAA receptorHippocampal formationCell biologyNeuroscienceReceptorProgenitor cellStem cellGlutamate receptorBiochemistry

MeSH Terms

AnimalsApoptosisCell ProliferationCell SurvivalGABA-B Receptor AntagonistsHippocampusMiceMiceKnockoutNeural Stem CellsNeurogenesisNeuronsOrganophosphorus CompoundsReceptorsGABA-AReceptorsGABA-BSignal Transductiongamma-Aminobutyric Acid

Affiliated Institutions

University of Basel CH

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Publication Info

Year: 2013
Type: article
Volume: 141
Issue: 1
Pages: 83-90
Citations: 111
Access: Closed

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APA Style

                            
                                
                                    Claudio Giachino, 
                                
                                    Michael Barz, 
                                
                                    Jan S. Tchorz
                                
                                et al.
                            
                            (2013). 
                            GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors. 
                            Development
                            , 141
                            (1)
                            , 83-90.
                            https://doi.org/10.1242/dev.102608
                        

Identifiers

DOI: 10.1242/dev.102608
PMID: 24284211

Data Quality

Data completeness: 90%