Abstract
New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step‐wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity‐dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis.
Keywords
GABAergicNeurogenesisNeuroscienceHippocampusBiologyDepolarizationInhibitory postsynaptic potentialEndocrinology
MeSH Terms
AdultAdult Stem CellsCell DifferentiationCell ProliferationHumansNeuronsNeurotransmitter AgentsReceptorsGABASignal Transductiongamma-Aminobutyric Acid
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Publication Info
- Year
- 2008
- Type
- review
- Volume
- 586
- Issue
- 16
- Pages
- 3745-3749
- Citations
- 44
- Access
- Closed
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Cite This
Sean J. Markwardt,
Linda Overstreet‐Wadiche
(2008).
GABAergic signalling to adult‐generated neurons.
The Journal of Physiology
, 586
(16)
, 3745-3749.
https://doi.org/10.1113/jphysiol.2008.155713
Identifiers
- DOI
- 10.1113/jphysiol.2008.155713
- PMID
- 18511482
- PMCID
- PMC2538938