Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

Keywords

Genome-wide association studyBiologySingle-nucleotide polymorphismEducational attainmentMultifactorial InheritanceHeritabilityGenetic associationGeneticsSNPGeneGenotype

Affiliated Institutions

Related Publications

Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels

Richa Saxena , Benjamin F. Voight , Valeriya Lyssenko +64 more

New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (...

2007 Science 2875 citations

A Genome-Wide Association Study of Type 2 Diabetes in Finns Detects Multiple Susceptibility Variants

Laura J. Scott , Karen L. Mohlke , Lori L. Bonnycastle +38 more

Identifying the genetic variants that increase the risk of type 2 diabetes (T2D) in humans has been a formidable challenge. Adopting a genome-wide association strategy, we genot...

2007 Science 2757 citations

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani , Jie Zheng , Benjamin Elsworth +17 more

Results from genome-wide association studies (GWAS) can be used to infer causal relationships between phenotypes, using a strategy known as 2-sample Mendelian randomization (2SM...

2018 eLife 7706 citations

Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

Paul R. Burton , David Clayton , Lon R. Cardon +97 more

There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We descri...

2007 Nature 9552 citations

Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation

Jun Z. Li , Devin M. Absher , Hua Tang +8 more

Human genetic diversity is shaped by both demographic and biological factors and has fundamental implications for understanding the genetic basis of diseases. We studied 938 unr...

2008 Science 2041 citations

Publication Info

Year: 2018
Type: review
Volume: 50
Issue: 8
Pages: 1112-1121
Citations: 2717
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2717

OpenAlex

Cite This

APA Style

                            
                                
                                    James J. Lee, 
                                
                                    Robbee Wedow, 
                                
                                    Aysu Okbay
                                
                                et al.
                            
                            (2018). 
                            Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. 
                            Nature Genetics
                            , 50
                            (8)
                            , 1112-1121.
                            https://doi.org/10.1038/s41588-018-0147-3
                        

Identifiers

DOI: 10.1038/s41588-018-0147-3