Abstract
The Gene Ontology (GO; http://www.geneontology.org) is a community-based bioinformatics resource that supplies information about gene product function using ontologies to represent biological knowledge. Here we describe improvements and expansions to several branches of the ontology, as well as updates that have allowed us to more efficiently disseminate the GO and capture feedback from the research community. The Gene Ontology Consortium (GOC) has expanded areas of the ontology such as cilia-related terms, cell-cycle terms and multicellular organism processes. We have also implemented new tools for generating ontology terms based on a set of logical rules making use of templates, and we have made efforts to increase our use of logical definitions. The GOC has a new and improved web site summarizing new developments and documentation, serving as a portal to GO data. Users can perform GO enrichment analysis, and search the GO for terms, annotations to gene products, and associated metadata across multiple species using the all-new AmiGO 2 browser. We encourage and welcome the input of the research community in all biological areas in our continued effort to improve the Gene Ontology.
Keywords
OntologyMetadataDocumentationResource (disambiguation)Process ontologyOpen Biomedical OntologiesDisseminationBiologyComputer scienceSet (abstract data type)Suggested Upper Merged OntologyWorld Wide WebGene nomenclatureGene ontologyInformation retrievalUpper ontologyOntology-based data integrationData scienceSemantic WebGeneTaxonomy (biology)GeneticsEcology
Related Publications
The Gene Ontology project in 2008
The Gene Ontology (GO) project (http://www.geneontology.org/) provides a set of structured, controlled vocabularies for community use in annotating genes, gene products and sequ...
Creating the Gene Ontology Resource: Design and Implementation
The exponential growth in the volume of accessible biological information has generated a confusion of voices surrounding the annotation of molecular information about genes and...
The Gene Ontology resource: enriching a GOld mine
Abstract The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene produ...
The GOA database in 2009--an integrated Gene Ontology Annotation resource
The Gene Ontology Annotation (GOA) project at the EBI (http://www.ebi.ac.uk/goa) provides high-quality electronic and manual associations (annotations) of Gene Ontology (GO) ter...
Creating the gene ontology resource: design and implementation.
The exponential growth in the volume of accessible biological information has generated a confusion of voices surrounding the annotation of molecular information about genes and...
Publication Info
- Year
- 2014
- Type
- article
- Volume
- 43
- Issue
- D1
- Pages
- D1049-D1056
- Citations
- 3529
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
3529
OpenAlex
Cite This
The Gene Ontology Consortium
(2014).
Gene Ontology Consortium: going forward.
Nucleic Acids Research
, 43
(D1)
, D1049-D1056.
https://doi.org/10.1093/nar/gku1179
Identifiers
- DOI
- 10.1093/nar/gku1179