Abstract

ABSTRACT The genome sequence of the hyperthermophilic bacterium Thermotoga maritima MSB8 presents evidence for lateral gene transfer events between bacterial and archaeal species. To estimate the extent of genomic diversity across the order Thermotogales , a comparative genomic hybridization study was initiated to compare nine Thermotoga strains to the sequenced T. maritima MSB8. Many differences could be associated with substrate utilization patterns, which are most likely a reflection of the environmental niche that these individual species occupy. A detailed analysis of some of the predicted variable regions demonstrates many examples of the deletion/insertion of complete cassettes of genes and of gene rearrangements and insertions of DNA within genes, with the C or N terminus being retained. Although the mechanism for gene transfer in this lineage remains to be elucidated, this analysis suggests possible associations with repetitive elements and highlights the possible benefits of rampant genetic exchange to these species.

Keywords

BiologyThermotoga maritimaHorizontal gene transferGeneGenomeGeneticsLineage (genetic)Genome evolutionGenomic islandEvolutionary biologyEscherichia coli

MeSH Terms

Base SequenceDNABacterialDNACircularEnvironmentGene Expression RegulationBacterialGene Transfer TechniquesGenomePlantGeographyHot TemperatureModelsGeneticMolecular Sequence DataNucleic Acid HybridizationOligonucleotide Array Sequence AnalysisPhylogenyThermotoga maritima

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Publication Info

Year
2005
Type
article
Volume
187
Issue
14
Pages
4935-4944
Citations
45
Access
Closed

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Cite This

Emmanuel F. Mongodin, Ioana R. Hance, Robert T. DeBoy et al. (2005). Gene Transfer and Genome Plasticity in <i>Thermotoga maritima</i> , a Model Hyperthermophilic Species. Journal of Bacteriology , 187 (14) , 4935-4944. https://doi.org/10.1128/jb.187.14.4935-4944.2005

Identifiers

DOI
10.1128/jb.187.14.4935-4944.2005
PMID
15995209
PMCID
PMC1169497

Data Quality

Data completeness: 86%