Genes for Epilepsy Mapped in the Mouse

Matthew L. Rise; Wayne N. Frankel; John M. Coffin; Thomas N. Seyfried

doi:10.1126/science.1871601

Abstract

The neurological mutant mouse strain El is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of backcrosses of El with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype ( El-1 ) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2 , linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.

Keywords

EpilepsyBiologyGeneticsPhenotypeSyntenyChromosomeGeneGenetic linkageNeuroscience

MeSH Terms

AnimalsChromosome MappingCrossesGeneticEpilepsyFemaleGenetic Predisposition to DiseaseMaleMiceMiceInbred StrainsMiceNeurologic MutantsRecombinationGeneticSeizuresSoftware

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Publication Info

Year: 1991
Type: article
Volume: 253
Issue: 5020
Pages: 669-673
Citations: 185
Access: Closed

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APA Style

                            
                                
                                    Matthew L. Rise, 
                                
                                    Wayne N. Frankel, 
                                
                                    John M. Coffin
                                
                                et al.
                            
                            (1991). 
                            Genes for Epilepsy Mapped in the Mouse. 
                            Science
                            , 253
                            (5020)
                            , 669-673.
                            https://doi.org/10.1126/science.1871601
                        

Identifiers

DOI: 10.1126/science.1871601
PMID: 1871601

Data Quality

Data completeness: 81%