Abstract
Searches for genes involved in the ageing process have been made in genetically tractable model organisms such as yeast, the nematode Caenorhabditis elegans, Drosophila melanogaster fruitflies and mice. These genetic studies have established that ageing is indeed regulated by specific genes, and have allowed an analysis of the pathways involved, linking physiology, signal transduction and gene regulation. Intriguing similarities in the phenotypes of many of these mutants indicate that the mutations may also perturb regulatory systems that control ageing in higher organisms.
Keywords
Model organismCaenorhabditis elegansDrosophila melanogasterBiologyAgeingGenePhenotypeGeneticsMutantSignal transductionGenetic modelGenetic screenComputational biology
MeSH Terms
AgingAnimalsCaenorhabditis elegansDrosophila ProteinsDrosophila melanogasterEnergy IntakeGene SilencingHistone DeacetylasesHormonesLongevityMutationNeuronsAfferentReproductionSignal TransductionSilent Information Regulator ProteinsSaccharomyces cerevisiaeSirtuin 2SirtuinsTrans-ActivatorsYeasts
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Publication Info
- Year
- 2000
- Type
- review
- Volume
- 408
- Issue
- 6809
- Pages
- 255-262
- Citations
- 1339
- Access
- Closed
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Cite This
Leonard Guarente,
Cynthia Kenyon
(2000).
Genetic pathways that regulate ageing in model organisms.
Nature
, 408
(6809)
, 255-262.
https://doi.org/10.1038/35041700
Identifiers
- DOI
- 10.1038/35041700
- PMID
- 11089983