Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe

Abstract

Our results warn against a priori assumptions of homogeneity among Finns and other seemingly isolated populations. Thus, in association studies in such populations, additional caution for population structure may be necessary. Our results illustrate that population history is often important for patterns of genetic variation, and that the analysis of hundreds of thousands of SNPs provides high resolution also for population genetics.

Keywords

International HapMap ProjectPopulationFounder effectSingle-nucleotide polymorphismPopulation geneticsBiologyGeographyEvolutionary biologyGenetic variationGenetic structureDemographic historyDemographyGeneticsImputation (statistics)HaplotypeGenotypeGeneMissing data

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Publication Info

Year: 2008
Type: article
Volume: 3
Issue: 10
Pages: e3519-e3519
Citations: 184
Access: Closed

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APA Style

                            
                                
                                    Elina Salmela, 
                                
                                    Tuuli Lappalainen, 
                                
                                    Ingegerd Fransson
                                
                                et al.
                            
                            (2008). 
                            Genome-Wide Analysis of Single Nucleotide Polymorphisms Uncovers Population Structure in Northern Europe. 
                            PLoS ONE
                            , 3
                            (10)
                            , e3519-e3519.
                            https://doi.org/10.1371/journal.pone.0003519
                        

Identifiers

DOI: 10.1371/journal.pone.0003519