Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

Paul J. Godowski; Sandro Rusconi; Roger L. Miesfeld; Keith R. Yamamoto

doi:10.1038/325365a0

Keywords

Glucocorticoid receptor5-HT5A receptorEnhancerHormone response elementEnzyme-linked receptorEstrogen-related receptor gammaNuclear receptor coactivator 2Nuclear receptorReceptorBiologyConstitutive androstane receptorCell biologyBiochemistryMolecular biologyEstrogen receptorTranscription factorGeneticsGene

Affiliated Institutions

University of California, San Francisco US

Related Publications

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

Mark Danielsen , Jeffrey P. Northrop , Jacqueline Jonklaas +1 more

We have analyzed the domain structure of the mouse glucocorticoid receptor by expression of in vitro mutated receptor in COS-7 cells. The receptor consists of a core domain rich...

1987 Molecular Endocrinology 174 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

Stanley M. Hollenberg , Vincent Giguère , Prudimar Segui +1 more

1987 Cell 510 citations

Mechanisms of transactivation by retinoic acid receptors

Hendrik G. Stunnenberg

Abstract Retinoids play an important role in development and differentiation (1,2) . Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ), A...

1993 BioEssays 155 citations

PGC-1-Related Coactivator, a Novel, Serum-Inducible Coactivator of Nuclear Respiratory Factor 1-Dependent Transcription in Mammalian Cells

Jan Andersson , Richard C. Scarpulla

The thermogenic peroxisome proliferator-activated receptor gamma (PPAR-gamma) coactivator 1 (PGC-1) has previously been shown to activate mitochondrial biogenesis in part throug...

2001 Molecular and Cellular Biology 365 citations

Oestradiol induction of a glucocorticoid-responsive gene by a chimaeric receptor

Stephen Green , Pierre Chambon

1987 Nature 439 citations

Publication Info

Year: 1987
Type: article
Volume: 325
Issue: 6102
Pages: 365-368
Citations: 427
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

427

OpenAlex

Cite This

APA Style

                            
                                
                                    Paul J. Godowski, 
                                
                                    Sandro Rusconi, 
                                
                                    Roger L. Miesfeld
                                
                                et al.
                            
                            (1987). 
                            Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement. 
                            Nature
                            , 325
                            (6102)
                            , 365-368.
                            https://doi.org/10.1038/325365a0
                        

Identifiers

DOI: 10.1038/325365a0