Abstract
Molecular events and mechanisms of ferroptosis to be unraveled and validated on animal models are GPx4 inactivation, role of GSH concentration, increased iron availability, and membrane structure and composition. This is expected to drive drug discovery that is aimed at halting cell death in degenerative diseases or boosting it in cancer cells. Antioxid. Redox Signal. 29, 61-74.
Keywords
GPX4Lipid peroxidationProgrammed cell deathChemistryPhospholipid-hydroperoxide glutathione peroxidaseBiochemistryGlutathioneCell biologyGPX1AntioxidantBiologyGlutathione peroxidaseEnzymeApoptosis
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Publication Info
- Year
- 2017
- Type
- review
- Volume
- 29
- Issue
- 1
- Pages
- 61-74
- Citations
- 624
- Access
- Closed
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Cite This
Matilde Maiorino,
Marcus Conrad,
Fulvio Ursini
(2017).
GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues.
Antioxidants and Redox Signaling
, 29
(1)
, 61-74.
https://doi.org/10.1089/ars.2017.7115
Identifiers
- DOI
- 10.1089/ars.2017.7115