Gross rearrangement breakpoint database (GRaBD?)

Shaun S. Abeysinghe; Peter D. Stenson; Michael Krawczak; D.N. Cooper

doi:10.1002/humu.20006

Abstract

Translocations and gross gene deletions are an important cause of both cancer and inherited disease. Such DNA rearrangements are nonrandomly distributed in the human genome as a consequence of selection for growth advantage and/or the inherent potential of some DNA sequences to be particularly susceptible to breakage and recombination. The Gross Rearrangement Breakpoint Database (GRaBD; http://www.uwcm.ac.uk/uwcm/mg/grabd/) was established primarily for the analysis of the sequence context of translocation and deletion breakpoints in a search for characteristics that might have rendered these sequences prone to rearrangement. GRaBD, which contains 397 germline and somatic DNA breakpoint junction sequences derived from 219 different rearrangements underlying human inherited disease and cancer, is the only comprehensive collection of gross gene rearrangement breakpoint junctions currently available.

Keywords

BreakpointBiologyGeneticsGene rearrangementContext (archaeology)GenomeGeneChromosomal translocationDNA sequencingHuman genomeGermline

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Publication Info

Year: 2004
Type: review
Volume: 23
Issue: 3
Pages: 219-221
Citations: 24
Access: Closed

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APA Style

                            
                                
                                    Shaun S. Abeysinghe, 
                                
                                    Peter D. Stenson, 
                                
                                    Michael Krawczak
                                
                                et al.
                            
                            (2004). 
                            Gross rearrangement breakpoint database (GRaBD?). 
                            Human Mutation
                            , 23
                            (3)
                            , 219-221.
                            https://doi.org/10.1002/humu.20006
                        

Identifiers

DOI: 10.1002/humu.20006