Growth and metastasis of surgical specimens of human breast carcinomas in SCID mice.

Abstract

Further examination of the heterogeneous properties of primary human breast carcinomas within SCID mice may provide a simple yet valuable new approach for the long-term study of human breast cancer biology. Importantly, use of the protocol described here can often permit the isolation of substantial quantities of human breast cancer cells for biochemical and molecular analyses. The ability to passage patients' breast tumors into large numbers of mice will permit the preclinical testing of new therapies for the treatment and prevention of this disease.

Keywords

Affiliated Institutions

• University at Buffalo, State University of New York US
• Buffalo State University US
• Roswell Park Comprehensive Cancer Center US

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