Abstract
Mutations in the Caenorhabditis elegans genes lin-14 , lin-28 , and lin-29 cause heterochronic developmental defects: the timing of specific developmental events in several tissues is altered relative to the timing of events in other tissues. These defects result from temporal transformations in the fates of specific cells, that is, certain cells express fates normally expressed by cells generated at other developmental stages. The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochrony is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.
Keywords
HeterochronyBiologyCaenorhabditis elegansCaenorhabditisGeneMutantGeneticsDevelopmental biologyMutationNematodeEvolutionary biologyIdentification (biology)Model organismOntogenyEcology
Affiliated Institutions
Related Publications
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, ...
High-Throughput Gene Mapping in <i>Caenorhabditis elegans</i>
Positional cloning of mutations in model genetic systems is a powerful method for the identification of targets of medical and agricultural importance. To facilitate the high-th...
Expansion<i>in vitro</i>of adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability
Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that al...
Morphogenesis of the Polarized Epithelial Cell Phenotype
Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelia...
Coordinately and differentially mutable activities of torpedo, the Drosophila melanogaster homolog of the vertebrate EGF receptor gene.
Abstract The torpedo (top) locus of Drosophila encodes the fruitfly homolog of the vertebrate epidermal growth factor receptor gene and the neu proto-oncogene. We have isolated ...
Publication Info
- Year
- 1984
- Type
- article
- Volume
- 226
- Issue
- 4673
- Pages
- 409-416
- Citations
- 812
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
812
OpenAlex
Cite This
Victor Ambros,
H. Robert Horvitz
(1984).
Heterochronic Mutants of the Nematode <i>Caenorhabditis elegans</i>.
Science
, 226
(4673)
, 409-416.
https://doi.org/10.1126/science.6494891
Identifiers
- DOI
- 10.1126/science.6494891