Abstract

Highly polymorphic repeated DNA sequences were detected at the end of the long arm of human chromosome 18 by a recombinant DNA probe containing 56 bp of human DNA (pERT25). This was shown by hybridization of pERT25 to DNA from a panel of human × rodent somatic cell hybrids, by dot blot hybridization to flow-sorted human chromosomes, and by in situ hybridization to metaphase chromosomes. The high degree of polymorphism detected by this 18q DNA fragment makes it potentially useful for various applications, including investigations into the genetics of trisomy 18 (Edwards syndrome), linkage studies, and paternity testing.

Keywords

BiologyChromosome 22Molecular biologyGeneticsSouthern blotMetaphaseChromosome 17 (human)DNAChromosome 16Human genomeChromosome 21In situ hybridizationChromosomeChromosome 3Hybridization probeGeneGenomeGene expression

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Publication Info

Year
1987
Type
article
Volume
45
Issue
1
Pages
16-20
Citations
17
Access
Closed

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U. Müller, Timothy A. Donlon, Peter C. Harris et al. (1987). Highly polymorphic DNA sequences in the distal region of the long arm of human chromosome 18. Cytogenetic and Genome Research , 45 (1) , 16-20. https://doi.org/10.1159/000132418

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DOI
10.1159/000132418