Abstract
The immune system responds in a regulated fashion to microbes and eliminates them, but it does not respond to self-antigens. Several regulatory mechanisms function to terminate responses to foreign antigens, returning the immune system to a basal state after the antigen has been cleared, and to maintain unresponsiveness, or tolerance, to self-antigens. Here, recent advances in understanding of the molecular bases and physiologic roles of the mechanisms of immune homeostasis are examined.
Keywords
Immune systemHomeostasisAntigenClearanceImmunologyBiologyFunction (biology)Immune toleranceCell biologyMedicine
MeSH Terms
AnimalsAntigensApoptosisAutoantigensAutoimmune DiseasesB-LymphocytesClonal AnergyHomeostasisHumansLymphocyte ActivationMiceSelf ToleranceT-Lymphocytes
Affiliated Institutions
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 280
- Issue
- 5361
- Pages
- 243-248
- Citations
- 962
- Access
- Closed
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Cite This
Luk Van Parijs,
Abul K. Abbas
(1998).
Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off.
Science
, 280
(5361)
, 243-248.
https://doi.org/10.1126/science.280.5361.243
Identifiers
- DOI
- 10.1126/science.280.5361.243
- PMID
- 9535647