Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI

Abstract

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by T H 1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.

Keywords

BiologyGeneHomology (biology)CytokineVirusVirologyOpen reading frameEpstein–Barr virusGenomeMolecular biologyGeneticsPeptide sequence

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Publication Info

Year: 1990
Type: article
Volume: 248
Issue: 4960
Pages: 1230-1234
Citations: 1147
Access: Closed

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APA Style

                            
                                
                                    Kevin W. Moore, 
                                
                                    Paulo Vieira, 
                                
                                    David Fiorentino
                                
                                et al.
                            
                            (1990). 
                            Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI. 
                            Science
                            , 248
                            (4960)
                            , 1230-1234.
                            https://doi.org/10.1126/science.2161559
                        

Identifiers

DOI: 10.1126/science.2161559