Abstract
We present a method for setting up topographically ordered mappings between two sheets of nerve cells. A set of chemical markers that express the neighborhood relationships within the presynaptic sheet is induced by the fibers into the postsynaptic sheet. The markers are used to guide the fibers to their terminal sites. A case for which this idea may be relevant is the retinotectal projection; our model exhibits types of plasticity found experimentally. The fact that the postsynaptic markers remain after removal of the projecting fibers suggests an important difference between development and regeneration. This paper concentrates on explaining the basic idea, and in addition presents a set of preliminary computer simulations.
Keywords
Postsynaptic potentialNeuroscienceRegeneration (biology)Terminal (telecommunication)Set (abstract data type)InterconnectionProjection (relational algebra)Computer scienceBiologyBiophysicsCell biologyReceptorBiochemistryAlgorithmTelecommunications
Related Publications
EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses
To study cellular and subcellular localizations of the glutamate transporter EAAT4, antibody was raised against the N-terminal peptide. On immunoblotting the antibody recognized...
Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus
1. Whole-cell patch-clamp recordings of excitatory postsynaptic currents (EPSCs) were made from guinea pig hippocampal CA1 pyramidal cells. The sensitivity of paired pulse facil...
The Time Course of Glutamate in the Synaptic Cleft
The peak concentration and rate of clearance of neurotransmitter from the synaptic cleft are important determinants of synaptic function, yet the neurotransmitter concentration ...
Publication Info
- Year
- 1977
- Type
- article
- Volume
- 74
- Issue
- 11
- Pages
- 5176-5178
- Citations
- 175
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
175
OpenAlex
Cite This
C. von der Malsburg,
David Willshaw
(1977).
How to label nerve cells so that they can interconnect in an ordered fashion..
Proceedings of the National Academy of Sciences
, 74
(11)
, 5176-5178.
https://doi.org/10.1073/pnas.74.11.5176
Identifiers
- DOI
- 10.1073/pnas.74.11.5176