Abstract
Huntington's disease (HD) is an autosomal dominant disorder of midlife onset, characterized by progressive involuntary choreiform movements, psychologic change, and dementia. In 1980, funded by the NINCDS, we established a center for the study of HD. This report presents a summary of our contributions to the investigation of this tragic disorder and a review of current ideas about the disease.
Keywords
Choreiform movementHuntington's diseaseDiseaseDementiaPsychologyDegenerative diseasePsychiatryMedicinePhysical medicine and rehabilitationCentral nervous system diseaseNeurosciencePathologyDyskinesiaParkinson's disease
MeSH Terms
AcetylcholineAdultAge FactorsBasal GangliaDNADopamineGenesDominantGlutamatesHumansHuntington DiseasePolymorphismGeneticPrenatal DiagnosisSomatostatingamma-Aminobutyric Acid
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Publication Info
- Year
- 1984
- Type
- review
- Volume
- 34
- Issue
- 8
- Pages
- 1059-1059
- Citations
- 165
- Access
- Closed
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Cite This
Joseph B. Martin
(1984).
Huntington's disease.
Neurology
, 34
(8)
, 1059-1059.
https://doi.org/10.1212/wnl.34.8.1059
Identifiers
- DOI
- 10.1212/wnl.34.8.1059
- PMID
- 6146951