Abstract

No growth factors specific for the lymphatic vascular system have yet been described. Vascular endothelial growth factor (VEGF) regulates vascular permeability and angiogenesis, but does not promote lymphangiogenesis. Overexpression of VEGF-C, a ligand of the VEGF receptors VEGFR-3 and VEGFR-2, in the skin of transgenic mice resulted in lymphatic, but not vascular, endothelial proliferation and vessel enlargement. Thus, VEGF-C induces selective hyperplasia of the lymphatic vasculature, which is involved in the draining of interstitial fluid and in immune function, inflammation, and tumor metastasis. VEGF-C may play a role in disorders involving the lymphatic system and may be of potential use in therapeutic lymphangiogenesis.

Keywords

LymphangiogenesisLymphatic systemVascular endothelial growth factor CLymphatic EndotheliumLymphatic vesselAngiogenesisVascular permeabilityVascular endothelial growth factorPathologyCancer researchHyperplasiaInflammationGenetically modified mouseBiologyTransgeneMedicineVascular endothelial growth factor AVEGF receptorsImmunologyMetastasisInternal medicineCancer

MeSH Terms

AnimalsCell DivisionCloningMolecularEndothelial Growth FactorsEndotheliumLymphaticEndotheliumVascularHumansHyperplasiaImmunohistochemistryIn Situ HybridizationLymphatic SystemMiceMiceInbred C57BLMiceInbred DBAMiceTransgenicMolecular Sequence DataRNAMessengerReceptor Protein-Tyrosine KinasesReceptorsCell SurfaceReceptorsGrowth FactorReceptorsVascular Endothelial Growth FactorSkinVascular Endothelial Growth Factor CVascular Endothelial Growth Factor Receptor-3

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Publication Info

Year
1997
Type
article
Volume
276
Issue
5317
Pages
1423-1425
Citations
1289
Access
Closed

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Cite This

Michael Jeltsch, Arja Kaipainen, Vladimir Joukov et al. (1997). Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice. Science , 276 (5317) , 1423-1425. https://doi.org/10.1126/science.276.5317.1423

Identifiers

DOI
10.1126/science.276.5317.1423
PMID
9162011

Data Quality

Data completeness: 81%