Abstract
Activated phagocytes generate the potent oxidant hypochlorite (HOCl) via the release of the enzyme myeloperoxidase and hydrogen peroxide. HOCl is known to react with a number of biological targets including proteins, DNA, lipids and cholesterol. Proteins are likely to be major targets for reaction with HOCl within a cell due to their abundance and high reactivity with HOCl. This review summarizes information on the rate of reaction of HOCl with proteins, the nature of the intermediates formed, the mechanisms involved in protein oxidation and the products of these reactions. The predicted targets for reaction with HOCl from kinetic modeling studies and the consequences of HOCl-induced protein oxidation are also discussed.
Keywords
Hypochlorous acidHypochloriteChemistryHydrogen peroxideMyeloperoxidaseBiochemistryReactivity (psychology)EnzymeRedoxPeroxidaseOrganic chemistryInflammationBiology
MeSH Terms
Amino AcidsCatalysisHumansHydrogen PeroxideHypochlorous AcidKineticsOxidation-ReductionPeptidesPeroxidaseProteins
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Publication Info
- Year
- 2003
- Type
- review
- Volume
- 25
- Issue
- 3-4
- Pages
- 259-274
- Citations
- 576
- Access
- Closed
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Cite This
Clare L. Hawkins,
David I. Pattison,
Michael J. Davies
(2003).
Hypochlorite-induced oxidation of amino acids, peptides and proteins.
Amino Acids
, 25
(3-4)
, 259-274.
https://doi.org/10.1007/s00726-003-0016-x
Identifiers
- DOI
- 10.1007/s00726-003-0016-x
- PMID
- 14661089