Abstract
An interactive procedure has been developed to assign sequences for the design of nucleic acid secondary structure. The primary goal of the procedure is to facilitate macromolecular architecture studies through the design of branched nucleic acid mono- and oligo-junction constructs in a convenient fashion. The essential feature of the sequence-symmetry minimization algorithm employed is the treatment of short sequences as vocabulary elements whose repetition decreases control over the resulting secondary structure. Both manual and semi-automatic application of this approach are available. The design of linear nucleic acid molecules or molecules containing single-stranded loops or connectors is also possible through application of the procedure.
Keywords
Nucleic acidNucleic acid structureSequence (biology)Protein secondary structureComputer scienceMacromoleculeComputational biologyChemistryBiochemistryBiologyRNA
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Publication Info
- Year
- 1990
- Type
- article
- Volume
- 8
- Issue
- 3
- Pages
- 573-581
- Citations
- 338
- Access
- Closed
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Cite This
Nadrian C. Seeman
(1990).
<i>De Novo</i>Design of Sequences for Nucleic Acid Structural Engineering.
Journal of Biomolecular Structure and Dynamics
, 8
(3)
, 573-581.
https://doi.org/10.1080/07391102.1990.10507829
Identifiers
- DOI
- 10.1080/07391102.1990.10507829